What is IVF MORE?
IVF MORE® (Magnetic Ovulatory Restoration) is a revolutionary egg restoration technique that improves egg quality in women with low ovarian reserve, advanced maternal age, or medical conditions affecting their reproductive capacity.
Traditionally, when a woman’s eggs presented metabolic dysfunction, structural disorganization, or impaired cell division, the only viable alternative was egg donation. IVF MORE® transforms this paradigm by offering a scientific, patented approach to restore and optimize a patient’s own eggs, making pregnancy possible with her own genetic material.
This procedure integrates multiple scientific advancements, including:
- Advanced metabolic egg diagnosis: Evaluating the egg’s energy levels through molecular analysis.
- Infusion of specific growth factors: Using essential metabolites to improve mitochondrial function.
- Application of magnetic fields: Optimizing the egg’s cytoskeleton to enhance cell division and reduce genetic errors.
- Improved embryo culture conditions: Reducing oxidative stress and optimizing cellular signaling.
Age in Fertility
The Problem: Egg Quality Deterioration
As women age, eggs undergo metabolic and structural alterations that impact their ability to develop into viable embryos. These alterations include:
- Decreased ATP production: Poor egg metabolism affects cell division.
- Increased oxidative stress: Reactive oxygen species (ROS) damage egg DNA and mitochondria.
- Cytoskeletal disorganization: Internal structures that maintain the egg’s shape and division ability become impaired.
- Genetic signaling errors: Disruptions in gene activation required for embryo development.
These factors contribute to the formation of aneuploid embryos (with chromosomal abnormalities), increasing the risk of miscarriage or implantation failure
The Solution: Egg Restoration with IVF MORE®
1. Advanced Metabolic Diagnosis
Before restoration, a metabolic assessment of the eggs is performed. Egg cytoplasm samples are analyzed for ATP, NADPH, and other key molecules. If deficiencies are detected, the restoration process begins.
2. Infusion of Growth Factors & Metabolic Regulators
Growth factors derived from the patient’s own cytoplasm are injected, along with metabolic cofactors that enhance mitochondrial function. This process restores energy production and reduces oxidative stress.
3. Magnetic Field Application
One of IVF MORE®’s most innovative features is the use of magnetic fields to reorganize the egg’s internal structure. The cytoskeleton inside an egg acts as a “scaffold.” If these structures are disorganized, cell division is compromised, leading to genetic abnormalities.
The application of a controlled magnetic field during embryo culture:
- Improves mitochondrial distribution inside the egg.
- Regulates calcium and magnesium channels, essential for cell division.
- Optimizes energy expenditure, allowing the egg to focus on proper development.
4. Enhanced Fertilization & Embryo Culture
Once restored, the eggs are fertilized and cultured under optimized conditions. Studies show that embryos derived from restored eggs have:
✔ Higher blastocyst formation rates (advanced embryo stage).
✔ Lower incidence of chromosomal abnormalities, reducing the need for egg donation.
How an Egg Becomes a Viable Embryo
To generate a viable embryo, an egg must function efficiently in metabolism and cellular structure. However, due to aging or medical conditions, eggs may lose their division capacity and developmental potential, reducing the chances of a successful pregnancy.
1. Key Requirements for a Viable Egg
✔ Sufficient Cellular Energy
- Eggs require adequate ATP production for correct post-fertilization division.
- With age, ATP generation declines, increasing the risk of genetic errors.
✔ Cytoskeletal Integrity
- The egg’s internal microfibers support its structure and division process.
- If disorganized, chromosomal misalignment occurs, leading to genetic abnormalities.
✔ Correct Genetic Signaling & Metabolic Pathways
- Eggs activate specific genes regulating development and embryo formation.
- Metabolic pathways impact energy efficiency:
- Aerobic (optimal) → Efficient energy production.
- Anaerobic (inefficient) → Leads to toxic waste buildup.
- Low-quality eggs tend to rely on anaerobic metabolism, reducing embryo viability.
2. Differences Between Restored & Non-Restored Eggs
Characteristics
Non-Restored Eggs
🟢 Restored Eggs with IVF MORE®
Studies show that in women with poor egg quality, IVF MORE® can triple viable embryo rates and reduce chromosomal abnormalities from 82% to 26%, providing a groundbreaking alternative for those seeking pregnancy with their own eggs.
Demographic Trends
1. Delayed Motherhood
Over the past few decades, women have been postponing motherhood for various reasons:
✔ Prioritizing career development and financial stability.
✔ Increased access to contraceptive methods.
✔ Changes in family and relationship dynamics.
✔ Rising average age for first-time mothers in many countries.
However, delaying pregnancy has a direct impact on fertility, as egg quality progressively declines with age.
2. Impact on Egg Quality
Both ovarian reserve (the number of available eggs) and egg quality begin to decline significantly after age 35. This decline is caused by several factors:
✔ Natural Egg Loss:
Women are born with approximately 1-2 million eggs.
By age 30, only about 100,000 eggs remain.
By age 40, only 10,000 eggs are left, many of which exhibit metabolic impairments.
✔ Metabolic and Genetic Deterioration:
As women age, eggs accumulate DNA damage, increasing the risk of chromosomal abnormalities (such as Down syndrome).
Aged egg mitochondria produce less energy, affecting their ability to develop properly.
✔ Rising Infertility Rates:
1 in 6 couples face fertility challenges.
More than 50% of female infertility cases are directly linked to age-related ovarian decline.
Without medical intervention, the natural pregnancy rate after age 40 is below 5% per cycle.
Who Can Benefit from IVF MORE®?
IVF MORE® is ideal for:
Over the past few decades, women have been postponing motherhood for various reasons:
✔ Prioritizing career development and financial stability.
✔ Increased access to contraceptive methods.
✔ Changes in family and relationship dynamics.
✔ Rising average age for first-time mothers in many countries.
However, delaying pregnancy has a direct impact on fertility, as egg quality progressively declines with age.
Studies conducted on IVF MORE® have shown promising results:
✔ Higher viable embryo rates – In women with poor egg quality, viable embryos increased up to 3x, with 70% of restored embryos developing successfully.
✔ Lower genetic risks – Chromosomal abnormalities decreased from 82% to 26%, similar to young donor eggs.
✔ Higher implantation & pregnancy rates – Women over 40 who previously had no viable embryos can now conceive using their own eggs.
While IVF MORE® is a groundbreaking technique for egg restoration, it has certain limitations.
Who is NOT a Candidate for IVF MORE®?
The main limitation is a total absence of eggs. This technique improves egg quality but cannot create new eggs.
✔ Some women who have stopped menstruating may still produce at least one egg with ovarian stimulation.
✔ If an egg can be retrieved, IVF MORE® is a viable option for improving pregnancy chances.
✔ However, for a small group of patients who no longer produce eggs, IVF MORE® cannot be applied.
Alternative: Ovagen
For patients with extremely low ovarian function, we offer Ovagen, a treatment designed to reactivate ovarian function using growth factors and cellular regeneration.
If you’re unsure about your eligibility for IVF MORE®, our medical team can evaluate your case and recommend the best option.
Discover How IVF MORE® Can Help You Achieve Pregnancy
Learn more about the technique that restores your eggs.
Literature
Artículos, referencias MORE
Live Births Per intended Egg Retrieval SART : https://sartcorsonline.com/CSR/PublicSnapshotReport?/ClinicPKID=0&reportingYear=2022
Edad avanza, el óvulo comete errores genéticos: Large cytoplasm predisposes oocytes to meiotic errors: http://www.cdb.riken.jp/en/news/2017/researches/0629_10912.html#:~:text=The%20oocyte%27s%20large%20cytoplasm%20is,segregation%20errors%20observed%20during%20meiosis
Desregulación metabólica en los ovocitos de pacientes con baja reserva ovárica: Zhu, Q., Li, Y., Ma, J., Ma, H., & Liang, X. (2023). Potential factors result in diminished ovarian reserve: a comprehensive review. Journal of Ovarian Research, 16(1). https://doi.org/10.1186/s13048-023-01296-x
Envejecimiento y estrés oxidativo: https://pubmed.ncbi.nlm.nih.gov/34121193/ DOI: 10.1002/jcp.30468
Endometriosis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342681/pdf/jcm-12-04186.pdf + https://pubmed.ncbi.nlm.nih.gov/23834505/ + https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173290/pdf/nihms801246.pdf + https://pubmed.ncbi.nlm.nih.gov/31211846/
Ovario poliquístico: https://pubmed.ncbi.nlm.nih.gov/17148555/ + https://pubmed.ncbi.nlm.nih.gov/34552933/
Shoukhrat Mitalipov, Ph.D. / Center for Embryonic Cell and Gene Therapy : Meet Shoukhrat Mitalipov, Ph.D./ His pioneering work with mitochondria could help eliminate genetic disease
: https://www.ohsu.edu/embryonic-cell-gene-therapy-center/meet-shoukhrat-mitalipov-phd
Autologous Germline Mitochondria Energy Transfer : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545901/pdf/nihms880936.pdf
Magnetic Fields – Nature: https://www.nature.com/articles/srep37407