Mission: Innovation to Enhance Health

Our relentless pursuit of research and development leads to therapies and treatments with the power to improve our patients’ health through regenerative medicine, enabling them to live fuller and healthier lives.

Vision: Improving Lives Through Science

Our focus is on enhancing our patients’ health in an innovative and meaningful way. It’s not just about science; it’s about translating that science into real benefits for people, knowing that it makes a true difference.

Values: Commitment to Excellence

  • Excellence & Expertise: We strive for the highest standards in everything we do, from scientific research to patient care.
  • Practicality: Our approach is professional yet accessible, ensuring that our innovations are meaningful and available.
  • Integrity: Ethical standards are the foundation of our research.
  • Commitment: Our dedication to advancing healthcare is unwavering.
  • Innovation: We are constantly seeking new ways to improve health outcomes.

Development of the IVF MORE® Technique

IVF MORE® is not just an assisted fertilization procedure; it is the result of years of research in reproductive biotechnology, molecular biology, and advanced micromanipulation. Its development represents an unprecedented breakthrough in oocyte restoration, allowing women with poor egg quality or diminished ovarian reserve to have a new opportunity to conceive using their own eggs.

The Origin of MORE®

The development of IVF MORE® arose from the need to offer a real scientific solution for patients who previously had only one option: egg donation. For years, advancements in in vitro fertilization improved embryo selection and treatment efficiency, but egg quality remained a challenge without an effective solution.

With the support of Ingenes, Regenera, and the University of Oregon, a team of researchers led by Dr. Shoukhrat Mitalipov—pioneer in reproductive genetics with the potential of the mitochondria—focused on finding a way to revitalize low-quality eggs without compromising their genetic material. This led to the creation of IVF MORE®, a technique that restores cellular functionality in eggs before fertilization, optimizing their ability to divide and reducing the risk of genetic abnormalities.

Scientific Principles Behind IVF MORE®

The development of MORE® is based on a combination of advanced technologies that work at the cellular and metabolic levels to improve egg quality:

1. Oocyte Metabolic Diagnosis

  • The viability of the egg is evaluated through molecular analysis that measures its energy metabolism.
  • ATP and NADPH levels, key indicators of mitochondrial activity and the egg’s ability to divide properly, are identified.
  • Markers of apoptosis (programmed cell death) and structural deterioration are detected.

2. Oocyte Restoration with Advanced Micromanipulation

  • Through intracytoplasmic infusion, metabolic factors, mitochondrial precursors, and granulosa cells providing essential nutrients are incorporated.
    The oocyte cytoskeleton is reorganized, optimizing the alignment of internal fibers that ensure proper cell division.

3. Fertilization with Optimal Sperm Selection

  • Techniques such as microfluidics and Hyaluronan adhesion are used to select the most competent sperm.
  • The PICSI technique is applied, ensuring that only the highest-quality sperm fertilize the restored eggs.

4. Embryo Culture in Magnetic Fields

  • Exposure to magnetic fields has been shown to reduce oxidative stress in embryos, optimize gene expression, and improve cellular organization.
  • This allows for more stable embryonic development, promoting the formation of viable blastocysts with a lower risk of chromosomal abnormalities.
  • With magnetic fields, the embryo ‘s cells can divide accordingly.

A Scientific Breakthrough with Proven Results

IVF MORE® has changed the outlook for many women who previously had no other option but egg donation. Initial studies have shown that:

  • Oocyte restoration triples the likelihood of obtaining viable embryos in women with low ovarian reserve.
  • The risk of chromosomal abnormalities in embryos is reduced by up to 70%, making it comparable to levels observed in donor eggs.

The combination of MORE® with techniques such as Non-Invasive PGT-A allows for a more precise selection of embryos without compromising their viability.

The Future of Fertility with MORE®

The implementation of MORE® has required the adaptation of specialized laboratories equipped with cutting-edge micromanipulation technology, high-resolution microscopes, and devices for generating controlled magnetic fields.

Thanks to this development, patients now have a real alternative that preserves their genetic material and offers them the possibility of having a baby with their own eggs, even in cases where this was previously impossible.

IVF MORE® is not just a treatment—it is the evolution of assisted fertility.

Collaboration: Dr. Mitalipov and the Center for Cells and Therapy of Oregon

IVF MORE® has been developed in collaboration with Dr. Shoukhrat Mitalipov, a renowned scientist from Oregon Health & Science University (OHSU), one of the world’s leading institutions in genetic therapy and reproductive biotechnology.

Currently, this technique is in the process of being published in high-impact scientific journals and has already been successfully applied in more than 40 patients, resulting in over 19 babies born thanks to this technology.

With IVF MORE®, the future of fertility has changed. Now, more women have the opportunity to conceive with their own eggs, without the need for egg donation.

Innovation and Science That Transform Lives

A research-driven approach focused on what matters most: your family.

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