Step by Step

By addressing key aspects of egg health and cellular metabolism, IVF MORE® offers a scientifically advanced alternative for patients who would otherwise require donor eggs.

1. Ovarian Stimulation and Egg Retrieval

The process begins with ovarian stimulation to induce egg production. This protocol is personalized for each patient and follows an antagonist cycle with FSH, menotropin, and, in some cases, letrozole to optimize ovarian response.

 

  • If at least 1 viable egg is retrieved, a single stimulation cycle may be sufficient.
  • If egg quantity is low or quality is poor (dark color, granules, etc.), a second stimulation is recommended to increase the number of eggs before restoration.

Once collected, the eggs are vitrified along with:
• The sperm sample (if applicable).
• Granulosa cells, essential for the restoration process.

2. Egg Metabolic Diagnosis

Before restoration, we perform a molecular evaluation of the egg’s metabolism using tools such as digital PCR and metabolite analysis.

This diagnostic process allows us to:

  • Identify apoptosis markers (programmed cell death).
  • Evaluate ATP and NADPH production, which are crucial in the Krebs cycle.
  • Determine if the egg has enough energy to divide properly.

If an egg presents energy deficits, its restoration is customized with growth factors and mitochondrial precursors.

3. Oocyte Restoration: The Core of IVF MORE®

MORE® oocyte restoration is based on advanced micromanipulation and regenerative biotechnology to revitalize eggs before fertilization.

The procedure includes:

  • Intracytoplasmic infusion of energy and growth factors.
  • Use of granulosa cells to supply key metabolites.
  • Cytoskeletal restructuring to optimize cell division.

By restoring the egg's metabolism, IVF MORE® drastically reduces the risk of chromosomal abnormalities and increases the chances of obtaining a viable embryo.

4. In Vitro Fertilization with Optimized Sperm Selection

To ensure effective fertilization, we use:

  • Microfluidics for sperm selection → Only the most motile sperm advance through a channel, eliminating those with morphological defects.
  • Hyaluronan binding → Mimicking natural selection, ensuring that the selected sperm are the most competent.
  • PICSI technique → Physiological Intracytoplasmic Sperm Injection using sperm with optimal characteristics.

This approach maximizes the probability of successful fertilization and the formation of high-quality embryos.

5. Magnetic Field Culture: Optimized Embryo Development

The obtained embryos are cultured in a specialized magnetic field environment, which has been shown to:

  • Reduce oxidative stress and cellular inflammation.
  • Optimize embryonic cytoskeletal organization.
  • Facilitate proper gene expression and cell division.

This environment promotes the formation of viable blastocysts with a lower rate of genetic errors.

6. Embryo Transfer and Regenerative Medicine

Viable embryos are transferred in a deferred cycle, allowing the uterus to be optimally prepared.

  • Hormonal treatments (estrogen and progesterone) are used to thicken the endometrium.
  • In cases of low endometrial receptivity, Endogen®—a combination of platelet-rich plasma and growth factors—is recommended to improve implantation.
  • Mesenchymal stem cells can also be used in patients with extremely thin endometrium.

This comprehensive approach maximizes implantation rates and the chances of a successful pregnancy.

Additional Treatments

IVF MORE® is not only a groundbreaking advancement in egg restoration, but it also integrates with other innovative treatments that optimize egg quality, endometrial receptivity, and embryo genetic evaluation. 

OVAGEN®: Enhancing Egg Quality

For patients with low ovarian reserve, one of the main challenges is the quantity and quality of retrieved eggs. OVAGEN® is a regenerative medicine-based treatment designed to:

✔ Improve ovarian vascularization, enhancing nutrient delivery.
✔ Optimize follicular development, promoting the production of more eggs.
✔ Reactivate ovarian function in patients with diminished ovarian reserve.

The procedure involves the direct application of growth factors and regenerative proteins into the ovary, extracted from the patient’s own blood plasma. Research has shown that women who previously did not produce eggs have regained ovarian activity and improved their response to stimulation.

How Does It Complement MORE®?

OVAGEN® allows patients with low egg production to obtain more oocytes, which can then be restored with IVF MORE®, increasing their chances of success.

ENDOGEN®: Optimizing Endometrial Receptivity

The endometrium plays a crucial role in embryo implantation. For an embryo restored with IVF MORE® to successfully implant, the endometrium must be in optimal condition.

ENDOGEN® is a treatment that utilizes growth factors and mesenchymal stem cells to improve endometrial quality in patients with:

✔ Thin endometrium or low receptivity.
✔ Recurrent implantation failure leading to miscarriage.
✔ Conditions such as endometriosis or Asherman’s syndrome.

The Procedure Is Simple:

  1. Platelet-rich plasma (PRP) is extracted from the patient.
  2. It is combined with endometrial growth factors and, in some cases, mesenchymal stem cells.
  3. The solution is applied directly to the endometrium before embryo transfer.

How Does It Complement MORE®?

After restoring eggs and obtaining viable embryos with IVF MORE®, ENDOGEN® enhances uterine conditions to increase implantation rates.

Non-Invasive Genetic Screening:

PGT-A Without Biopsy

One of the most significant advances in fertility treatment is the ability to analyze the genetic health of embryos without requiring a biopsy.

How Does It Work?
Instead of extracting cells from the embryo, as in conventional biopsy-based testing, we use an advanced technique that analyzes cell-free DNA released by the embryo into the culture medium.

Benefits of Non-Invasive PGT-A:

  • Less stress on the embryo: No need to puncture the embryo’s outer layer.
  • Highly accurate detection of chromosomal abnormalities: Identifying conditions like Down syndrome, Turner syndrome, Klinefelter syndrome, and others.
  • Fast and reliable results: Without compromising embryo viability.

How Does It Complement MORE®?

IVF MORE® reduces genetic abnormalities in embryos, for additional safety, we offer Non-Invasive PGT-A as an extra step in embryo evaluation.

Compatibility with Previously Frozen Eggs

If you previously froze eggs with the hope of using them in the future, IVF MORE® can help optimize their chances of success.

How Does It Work?

  1. Your frozen eggs are transported to our Ingenes Mexico laboratories.
  2. We conduct a metabolic diagnosis to evaluate their quality.
  3. IVF MORE® is applied to restore the eggs before fertilization.

When Is It Recommended to Restore Frozen Eggs?

  • If you froze your eggs after age 35.
  • If your eggs show signs of poor quality upon thawing.
  • If you’ve had previous failed fertilization attempts with your frozen eggs.

Are Your Eggs Stored in Another Clinic or Country?

No problem! At Ingenes, we work with specialized biological material transport companies and can coordinate the safe transfer of your eggs to Mexico, ensuring they arrive in optimal conditions for restoration.

A Personalized Treatment for Every Patient

Whether you need to Optimize your egg quality with OVAGEN®, improve endometrial receptivity with ENDOGEN®, or perform non-invasive genetic testing with PGT-A, each of these treatments complements the MORE® methodology to provide you with the best chance of achieving a healthy pregnancy.

Take the Next Step Toward Growing Your Family

We’re here to support you at every stage of the journey.

Consult with our specialists