IVF MORE®: The Innovative Technique for Egg Restoration
A pioneering approach in assisted reproduction, IVF MOREⓇ (Magnetic Ovulatory Restoration) is an exclusive technique that utilizes advanced ovarian restoration to improve egg quality. Creating a unique pathway to pregnancy without the need for an egg donor, IVF MOREⓇ offers new possibilities for those facing fertility challenges, especially women over 40 who wish to become mothers.
Understanding the Role of Age in Human Reproduction
Age is the main factor affecting fertility in women, as egg quality declines with aging, especially after 35 years, according to the World Health Organization. This fertility reduction is associated with a lower quantity and reduced quality of eggs. Additionally, the risk of miscarriage also increases with age, being more likely after 40.
Before IVF MORE®, options were limited for these patients, often resorting to egg donation. IVF MORE® offers an alternative through ovarian restoration, providing a better chance for eggs to divide correctly and result in a viable embryo with the patient’s own genetics.
Egg quality typically deteriorates with age, making fertilization and early embryo development difficult due to the lack of necessary components and energy required for proper cell division and embryo formation in the cytoplasm.
This can cause genetic abnormalities that may be transmitted to the embryo, leading to developmental problems or implantation failures. While age is the most important factor, endometriosis and Polycystic Ovary Syndrome (PCOS) also negatively impact embryo viability.
One in six women may have endometriosis. This condition occurs when menstrual blood flows towards the ovaries, affecting egg production and quality. This can form cysts called endometriomas, making the eggs dark and granular, reducing their fertilization and development capacity. In PCOS, insulin resistance and excess androgens prevent eggs from maturing properly, increasing genetic abnormalities and miscarriage rates.
IVF MORE® offers new hope for these women, allowing the restoration of eggs even in women over 40, improving their chances of achieving a viable embryo.
IVF MORE® is specifically designed for individuals facing egg quality challenges due to:
- Advanced maternal age
- Endometriosis
- Polycystic Ovary Syndrome (PCOS)
- Repeated failed IVF attempts
- Embryos with genetic abnormalities (analyzed with PGT-A)
How Does IVF MORE® Work?
IVF MORE® is an innovative technique that restores low-quality eggs, increasing the chances of pregnancy using the patient’s own eggs.
The process begins with ovarian stimulation to retrieve eggs, which are then individually analyzed through metabolic diagnosis to assess their energy deficiency. Next, cytoplasmic restoration is performed using the patient’s own cells, replacing cellular energy and optimizing the egg’s fertilization capacity.
The best sperm cells are selected through advanced techniques, and in vitro fertilization is carried out. The resulting embryos are cultured in a magnetic field environment to support their development and ensure proper cell division.
Oocyte restoration allows for the reduction of genetic abnormalities, so that, ultimately, viable embryos can be transferred to the uterus under optimal conditions, increasing the chances of a successful pregnancy.
What is IVF MORE®?
IVF MORE® is our exclusive technique that improves egg quality by utilizing advanced technologies such as micromanipulation and magnetic fields. We use a patented and proprietary recipe that provides specific nutrients and conditions designed to revitalize and optimize the eggs, improving their ability to divide correctly and develop into viable embryos. By improving the fundamental aspects of egg health and development, IVF MORE® could potentially increase the chances of successful conception and healthy pregnancy.
Frequently Asked Questions
What is the total duration of the treatment?
The complete treatment takes approximately three months.
When is it recommended to accumulate more eggs?
With just one mature egg, we can proceed with the IVF MORE® technique. However, if no viable eggs are found, we recommend a second ovarian stimulation.
What are the limitations of this technique?
IVF MORE® is an advanced technique designed to restore egg quality. Its main limitation is the total absence of eggs, as the procedure requires at least one mature egg to be viable.
However, if a patient can still produce eggs through ovarian stimulation, IVF MORE® remains an option. In cases of extremely low ovarian function, Ovagen may serve as an alternative to reactivate ovarian function and improve the body’s response.
Ovagen is a regenerative medicine treatment aimed at stimulating ovarian function in patients with low ovarian reserve, promoting the production of more eggs.
If you are unsure whether the procedure is right for you, our medical team can evaluate your case and guide you toward the best option for your situation.
Our Success is Your Family: Results & Testimonials
Egg Banking
Our process starts with collecting the patient’s eggs. To increase the number of eggs collected, we use hormonal stimulation. If we obtain more than six eggs and they are of good quality, a single treatment session will suffice. However, if the eggs are few or have signs or low quality like dark color or granular aspect, we suggest a second stimulation session to ensure enough quality eggs before proceeding with our IVF MORE® technique. The goal is to freeze these eggs in less than six months. Even if a patient produces very few eggs, we can proceed with the IVF MORE® technique, as we only need at least one egg to attempt the treatment.
This approach maximizes the chances of successful outcomes by ensuring that eggs are collected and processed at their highest quality, while also adapting the approach if fewer eggs are available.
Metabolic Diagnosis
We have identified factors that allow us to detect the metabolic state of each egg and obtain a diagnosis. Some of these factors, such as Annexin V and other Krebs Cycle markers, determine the correct metabolic development of the eggs. We will obtain a metabolic profile that tells us if the egg has enough metabolites to divide correctly and if it has enough energy to divide correctly.
This metabolic diagnosis allows for a more precise approach to egg quality assessment, enhancing the chances of successful fertilization and embryo development by focusing on the eggs with the most favorable metabolic conditions.
Oocyte Restoration:
We enhance the egg through the Regenera® method, a sophisticated approach to improving egg quality, which consists of an intracytoplasmic infusion to poor-quality oocytes with growth factors and essential energy components derived from the patient’s own cells to give the egg better chances of fertilizing and reducing the risk of producing an embryo with genetic abnormalities. This method uses advanced techniques such as biomolecular technology and digital PCR based on nanoplatelets to restore the eggs.
Overall, the Regenera® oocyte restoration method leverages cutting-edge technology and personalized components to significantly improve egg quality and increase the chances of successful embryo development.
In Vitro Fertilization (IVF):
We use the PICSI (Physiological Intracytoplasmic Sperm Injection) PICSI technique to fertilize the eggs. For this, it is essential to select the most capable sperm. There is an alternative where sperm, through a microfluidics technique, travel through a channel. In this process, the best-quality sperm manage to exit from one end of the microfluidics to the other. The selected sperm bind to hyaluronan, an essential component of the zona pellucida (the egg’s outer layer) of each egg. Simulating the natural process, we can filter and select the sperm that have the greatest ability to compete and advance through the microfluidic channel. By selecting sperm that bind to hyaluronan, the method enhances the likelihood of choosing sperm with the greatest potential for successful fertilization.
By integrating the PICSI technique with microfluidics for sperm selection, you enhance the precision of sperm choice, potentially leading to higher fertilization rates and better embryo quality. This approach optimizes the conditions for creating viable embryos, improving overall success in fertility treatments.
Magnetic Field Culture:
We have found that by leaving the restored eggs in magnetic fields, there is an intracytoplasmic movement of solutes that allows better organization of the egg’s cytoskeleton. Once fertilized, we increase the potential of the magnetic fields to allow the egg to spend less energy and divide correctly. In other words, the magnetic fields have significantly increased the possibility of producing viable embryos.
Embryo Transfer to the Uterus:
Once we have viable embryos, The process of embryo transfer to the uterus is a critical step in assisted reproduction. We prepare the recipient woman’s endometrium using endometrial preparation techniques including hormonal treatments (e.g., estrogen and progesterone) to thicken and stabilize the uterine lining, making it more receptive to the embryo.
In some cases, we use regenerative medicine techniques to increase the embryo’s implantation potential.
By combining meticulous endometrial preparation with advanced regenerative medicine techniques, the goal is to create the most favorable conditions for embryo implantation and increase the likelihood of a successful pregnancy.
Who Can Benefit from IVF MORE®
IVF MORE® offers a valuable alternative for individuals facing significant fertility challenges.
- Women over 40 who have seen their egg quality naturally decrease with age.
- Patients with a history of Unsuccessful IVF cycles. Convinced that they have exhausted their possibilities of conceiving with their eggs.
- Advanced endometriosis or Polycystic Ovary Syndrome (PCOS).
- Face fertility challenges due to genetic problems affecting embryo development.
- Patients who have had total embryo blockage.
- Patients who have undergone genetic embryo analysis and only get aneuploid (having an abnormal number of chromosomes) embryos
Overcoming Fertility Barriers Beyond Age
Although IVF success rates decrease after 35 years of age, IVF MORE® offers an innovative technique that enhances the fertilization process. This technique improves the chances of conceiving your eggs without resorting to egg donation. Instead of relying on younger donor eggs, IVF MORE® helps overcome the challenges of age, endometriosis, and PCOS, providing new hope for achieving a successful pregnancy.
Innovation That Transforms Lives: Our Story
In IVF MORE®, we combine cutting-edge science with regenerative medicine to offer new possibilities to those who dream of building a family. Our technique has been developed in collaboration with Dr. Shoukhrat Mitalipov and the Oregon Cell & Therapy Center, utilizing the latest advancements in molecular biology to restore low-quality eggs.
With over 19 babies born thanks to this technology and an upcoming publication in high-impact scientific journals, we continue advancing to provide innovative and accessible solutions in assisted reproduction.
Take the First Step Toward Your Baby with IVF MORE®
Our team is ready to support you at every step.